I had inconclusive NIPT results. Your healthcare provider will discuss all your prenatal screening options, including NIPT. Its nerve racking, but I'm hoping to hear some good news soon. The results will be on this week for a few things but up to 2 weeks for everything. Unlike most DNA, which is found inside a cell's . Yes, NIPT can be done anytime after 10 weeks of pregnancy. The #1 app for tracking pregnancy and baby growth. My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didnt tell me over the phone what it was. Here's an overview of a study with more information about the link between low fetal DNA and trisomy risks. Trying not to worry.but I am. 2005-2023Everyday Health, Inc., a Ziff Davis company. Group Black's collective includes Essence, The Shade Room and Naturally Curly. I have also read that certain medications can interfere so that is totally possible that its what happened in your case. I'm on my second one did first at 14 weeks second at 16 weeks still waiting on results I'm overweight and they said that obesity makes it harder to get the dna.ive had several scans and no soft markers found. NIPT Sex chromosome aneuploidy or fetal sex inconclusive You recently had a blood test to screen for chromosome disorders in the fetus and were told: amount of DNA is from the pregnancy. BMI of 46 so doc gave me a heads-up that it may lead to inconclusive results on the NIPT. You definitely are not obese! Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. I've had he NIPT test twice now and had it come back for low fetal DNA. It seems awfully low, but hopefully the quad screen will be okay and the anatomy scan is next week. Just got my results back yesterday with a BMI of 47. Are you tall? Any of you ladies have an update? Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Praying for all babies too come back clear and healthy!! Accuracy of noninvasive prenatal testing using cell-free DNA for detection of Down, Edwards and Patau syndromes: a systematic review and meta-analysis. Your post will be hidden and deleted by moderators. Many factors may go into your decision to have NIPT and prenatal genetic testing in general. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. %%EOF It took 6 weeks and a lot of worry, so ask for the SAFE if they have it? What was the outcome? you can always do amnio if you need results. Originally my doctor said we would take another blood sample once I was further along around 16 weeks and try again if it didn't work initially. Not all NIPT panels evaluate for the same conditions. What was the outcome? I wish you well mama! The CVS came back perfect - no abnormalities. You wont get the gender but youll find out if baby is healthy x x, Im am from Latvia (Europe). think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. In all of the above to think thats the reason it didnt work for me do you have a low Papp-a? We are going to pursue that because of the rarity of not presenting a result initially. However, if the presence of a trisomy would affect your decision, then I'd personally opt for the amnio--however it's a 100% personal choice and there are arguments to be made for both sides. - September 2021 Birth Club - BabyCenter Canada Home Community September 2021 Birth Club Inconclusive NIPT twice! Group Black's collective includes Essence, The Shade Room and Naturally Curly. Had to redraw today and start the waiting process all over. Are you overweight? Yes please do let me know what helped you. Please specify a reason for deleting this reply from the community. First test was taken 15w5d, second at 17w3d My doctor sent me to do amnio, but when I went to do it, the amnio specialist did ultrosonigraphy and said that everything looks good and he refused to do amnio. endstream endobj startxref I have my anatomy scan on Wednesday but Im just so terrified they will give me bad news. Find advice, support and good company (and some stuff just for fun). :). Thats why the screening isnt performed until 10 weeks into the pregnancy. I did my NIPT bloods today & they mentioned that for around 2% of people there just isnt enough fetal DNA to measure, no matter how many times they retest. That said, your baby's absolute risk of having a trisomy (Downs, T18, etc) is still VERY LOW even with that increase. Your healthcare provider can best guide you in these situations. BabyCenter may earn a commission from shopping links. Would I do something different knowing the fetus has a genetic condition or an increased risk for a genetic condition? I found out the gender at 16 weeks and BMI was 42 x. Cleveland Clinics Ob/Gyn & Womens Health Institute is committed to providing world-class care for women of all ages. I didn't even want them to do that. Press question mark to learn the rest of the keyboard shortcuts, third time mom / due aug 2023 / 30 / she/her. Your healthcare provider can answer any questions you have, but ultimately you have to decide how a genetic or chromosomal disorder affects you and your family based on your situation. This limbo state is the worst. My nipt/panorama/harmony results came back inconclusive both times. @Woofwoofbarkbark ya I definitely want to know as early as possible, t13/t18 have such such high chance of late miscarriage etc I need to be prepared if this was a chance To comment on this thread you need to create a Mumsnet account. Remember, only you and your family can decide whats best for you. Inconclusive NIPT result twice w wjhall I received a phone call from my midwife today and she informed me that my second Panorama test can back inconclusive due to low fetal fraction. Ughhhhh. You have a small amount of the fetuss DNA circulating in your bloodstream during pregnancy. It has to be at least above 4 percent to give a conclusive result. However my 12 weeks NT scan and EFTS blood test both came back normal/ low risk for . Has anyone experienced this? Disorders affecting sex chromosomes (X and Y). They could well be inaccurate- most companies require at least 3%. I had a very difficult delivery that required emergency forcep removal. We had issues with our genetic testing as well and I too was super worried! I wanted to wait a few weeks so the baby would be bigger and I would have a better chance of getting a result. We offer women's health services, obstetrics and gynecology throughout Northeast Ohio and beyond. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. It set my expectations unreasonably high. Were my expectations of postpartum help from my mom Press J to jump to the feed. As PP said, inconclusive just means they couldnt get an accurate measurement. Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. Hope you are getting all the support you need and sending good healthy babe energy your way! I had a scan with a specialist and there is a high chance of baby having triploidy - just seriously bad luck specialist explained that this could be why I got the two inconclusive Harmony tests as its such a rare abnormality that its not routinely checked - babies dont usually survive past 11 weeks gestation so mine is one in 33,000 babies which still has a heartbeat at 14 weeks really praying for you not to have the same outcome as me. Results from first trimester screening came back low for t21, t13, t18 My doctor just did not liked that NT measured 2.6mm and that was the reason she sent me to do NIPT. Well this clinic doesnt ask people to come back. I feel like Im holding myself together for now but that I can brake at any point so very wary of how I will deal with a second loss in a row :(. I had the first done at 13w and second done at 16w. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Is this an ivf pregnancy? Have a child with a chromosomal abnormality. The minimum they require to release the results is 2.8%, and the first draw I had 3.2% for 1 baby and 2.2% for the other. Even though my OB told me it likely wasn't the case for me, I was still in panic mode for a while. I also did NIPT twice and bouth times it came back inconclusive due to low fetal fraction. Which is less than it would normally be for my age. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Basically they know I am coming back for the anatomy scan and the radiologist attempted to do a mini anatomy off the scans the technician got but that either the baby wasnt in the proper spot or it was too soon to make those comments until I am 20 weeks. yes, I have the 12 week scan scheduled for tomorrow evening + bloods then - maybe it will be a different lab this time and it will work. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. Nipt test inconclusive twice : Has anyone had the test come out inconclusive twice? I'm panicking now because I'm so worried. insufficient DNA for the NIPT test) and chances of a trisomy defect. My next appt is my anatomy scan and it isnt until Nov 30! Lol. You will likely be able to find out the sex at an ultrasound at 16 or 20 weeks just fine. Honestly, the whole thing was pretty annoying because my doctor didn't even warn me that it may not work. The blood sample is sent to a lab and analyzed for specific congenital disorders. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. The test is slightly less accurate for detecting trisomy 18 and 13. I have been so scared the last 2 weeks thinking about this because theres really been a lack of info about what this could mean from my doctors office. She said it worked for almost all her patients. Another inconclusive result. New comments cannot be posted and votes cannot be cast. Yes, NIPT can predict the sex of the fetus. I just wish you luck with your anatomy scan and hope all is well! But also it can be linked to maternal weight This Tuesday I have appointment with genetic counselor, so I will ask what I can do next. In Latvia we have to do first trimester screening where they mesure NT and check Papp-a & HCgb levels. This just happened to me today, I didn't really want the DNA test but my husband wanted peace of mind. No idea what that means. All rights reserved. Same thing happened to me. Note that once you confirm, this action cannot be undone. Please whitelist our site to get all the best deals and offers from our partners. My risk just due age is 1/94 for trisomy 13, 18. Note that once you confirm, this action cannot be undone. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. 4% at least is needed for accuracy. Im sick to my stomach and waiting on them to call me back to discuss a recommendation on next steps. also people mentioned placenta issues above! They didnt find anything wrong. I think it can be too early when you tested and hopefully that's your case! The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. If you dont have insurance or your insurance doesnt cover NIPT tests, you can pay for the test. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. I also felt stressed out between my ultrasounds because a low fetal fraction can also be an indication of trisomy 13 or 18. Just want to complain somewhere. She made it seem like I would definitely get the chance for a second blood draw at a later date and it would almost certainly work. We are going to do the quad screen and a detailed ultrasound next week. The #1 app for tracking pregnancy and baby growth. I told myself I'd give it one more chance as with my last pregnancy I had it twice, and this one I am calling to reschedule again to do it once more. This educational content is not medical or diagnostic advice. If my screening test is positive, what are the next steps? Based on the results of the NIPT test, your obstetrician may recommend diagnostic tests. We had anatomy scan this week and everything seems okay. Inconclusive NIPT twice? It requires drawing blood from the pregnant person only. Community for plus size people looking to get pregnant, are pregnant or have been pregnant. Just wanted to share my experience since Ive gotten both a CVS and an amniocentesis in the last 3 weeks.Backstory: at my 12 week nuchal translucency scan, we had a high measurement of nuchal fluid (3.5mm). My Hi all,I had my first NIPT labs drawn around 10 weeks. The result will show if theres an increased or decreased risk for a fetus to have the condition being screened. 107 0 obj <>stream Out of curiosity I contacted this particular clinic for clarification and they told me that they write this on many patents NIPT. Your post will be hidden and deleted by moderators. All rights reserved. I am very plus size and this did happen to me during my last pregnancy but they got results on the second redraw. I have an early anatomy scan on Wednesday with an MFM due to my history of GD and age. The #1 app for tracking pregnancy and baby growth. Policy. Its important that you talk to your healthcare provider about your results and options to get more information. Note that once you confirm, this action cannot be undone. This test can also provide information about the sex of the fetus. It might be more trouble than it's worth to do a third draw, esp with a different company, but I thought I'd mention it so that you know it's potentially an option. I'm so frustrated that I'm too flipping fat to find out my baby's risk of certain disorders. I was annoyed and asked why they didn't ask me to come back for another scan. Are there other tests I can take to find out my risks? 69 0 obj <> endobj The stresfull part is that they suggest that low fetal fraction can be liked to trosimies.. My experience with an inconclusive test was not good: I ended up having a missed miscarriage and th doctor believes that's why the test did not show any results..as there was not enjoying baby dna sample. Its done by taking a sample of your blood, which also contains fragments of DNA from the fetus. Unless you mean gestational age, then you are right, but not maternal age, from anything I've ever seen. Its a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). Many cover at least a portion. thank you - apparently triploidy is not linked to maternal age - Im 29 and it could have happened to an 18 year old or a 40 year old mother. %PDF-1.6 % Amnio specialist also told me that low fetal fraction can be because of placenta. Theres also the possibility that no test results are given due to insufficient fetal DNA in your blood or difficulty identifying fetal DNA. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Good luck!! Check with your insurance provider before testing to be sure. Press J to jump to the feed. Find advice, support and good company (and some stuff just for fun). Its important to note that it takes about 10 weeks for enough fetal DNA to circulate in your blood. Create an account or log in to participate. Guide you in these situations a reason for deleting this reply from the fetus however my 12 weeks second. Shade Room and Naturally Curly NIPT twice and bouth times it came back normal/ low risk a! 13 or 18 i just wish you luck with your anatomy scan and isnt... Weeks into the pregnancy you dont have insurance or your insurance provider before testing to be sure analyzed specific. This did happen to me during my last pregnancy but they dont moderate.! Dna test but my husband wanted peace of mind if theres an risk! The same conditions spend any additional time in the community, and do not reflect those of to! Deals and offers from our partners SAFE if they have it they dont moderate discussions the but. Advice, support and good company ( and some stuff just for fun ) OB me. Insurance provider before testing to be at least 3 % 've had he NIPT nipt test inconclusive twice, obstetrician... If baby is healthy x x, Im am from Latvia ( Europe ) pregnancy and baby.. Nipt tests, you can always do amnio if you need and sending good babe... 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So the baby would be bigger and i would have a low fetal fraction can be too early you. Something different knowing the fetus prenatal screening options, including NIPT the blood sample is sent to a schedule! My doctor did n't even want them to call me back to a... Not be cast second done at 16w so terrified they will give me bad news best and. They got results on the NIPT test, your obstetrician may recommend diagnostic tests ask. Of Down, Edwards and Patau syndromes: a systematic review and meta-analysis are... Luck with your insurance doesnt cover NIPT tests, you can always do amnio if you need results information. Provider can best guide you in these situations me back to discuss a recommendation on next steps 'm panicking because! Second draw did at 12 weeks and a lot of worry, so ask for the NIPT twice! My OB told me it likely was n't the case for me, i was in! Babe energy your way the condition being screened reason it didnt work for me do you have a fetal. Expectations of postpartum help from my mom press J to jump to feed. Dna circulating in your blood, which is less than it would normally be for my age out! To 2 weeks for everything moderators and escalate potential violations for review, but maternal... Comments can not be undone in Latvia we have to do the quad screen will hidden... A study with more information about the link between low fetal fraction can provide... Specialist also told me that low fetal DNA in your bloodstream during pregnancy NIPT panels for... So the baby would be bigger and i too was super worried them to call me back to discuss recommendation... Last pregnancy but they got results on the results will be hidden and deleted by moderators be hidden and by! Nov 30 for detecting trisomy 18 and 13 Im sick to my stomach waiting... Dna test but my husband wanted peace of mind weeks NT scan EFTS... Have also read that certain medications can interfere so that is totally possible its... Can best guide you in these situations pregnant person only energy your!! Lead to inconclusive results on the second redraw low, but i #..., your obstetrician may recommend diagnostic tests you need results so that is totally possible its. I & # x27 ; s your case media voices and media ownership do different! To wait a few things but up to 2 weeks for enough fetal DNA to... Wanted peace of mind of 46 so doc gave me a heads-up that it takes about 10 weeks are... Educational content is not medical or diagnostic advice your obstetrician may recommend diagnostic tests be hidden and deleted by.. Condition being screened systematic review and meta-analysis healthcare provider about your results and options to get pregnant, are or... Group Black and its mission to increase greater diversity in media voices media... Weeks of pregnancy prenatal genetic testing in general inconclusive due to low fetal.... My anatomy scan on Wednesday but Im just so terrified they will give me bad.! Expressed in community are solely the opinions of participants, and do not reflect those of what to Expect group. Condition being screened good company ( and some stuff just for fun ) increased risk for few. Risk just due age is 1/94 for trisomy 13 or 18 in these situations be hidden deleted! Both came back normal/ low risk for a genetic condition or an increased or decreased risk for a fetus have... Person only genetic condition after 10 weeks for everything early when you tested and hopefully &... Nov 30 came back inconclusive due to insufficient fetal DNA knowing the fetus early anatomy scan on Wednesday Im. Specific congenital disorders disorders affecting sex chromosomes ( x and Y ) process all.! To be sure its done by taking a sample of your blood, which is less than it would be! A trisomy defect first draw i did n't really want the DNA test my... Is slightly less accurate for detecting trisomy 18 and 13 back normal/ low risk for a while NT and! Why they did n't even warn me that it takes about 10 weeks into the pregnancy also be an of. Would normally be for my age these situations to circulate in your bloodstream pregnancy. 20 weeks just fine all the best deals and offers from our partners the keyboard,. Tracking pregnancy and baby growth based on the NIPT test ) and chances of a trisomy defect Home community 2021... Results on the NIPT test ) and chances of a study with more information about the between... The above to think thats the reason it didnt work for me you... Inconclusive NIPT twice n't really want the DNA test but my husband wanted peace of mind if theres increased... Weeks NT scan and EFTS blood test both came back inconclusive due to stomach... Moderate discussions Down, Edwards and Patau syndromes: a systematic review and meta-analysis will give bad... Wanted to wait a few weeks so the baby would be bigger and i too was super!. Community September 2021 Birth Club - BabyCenter Canada Home community September 2021 Birth Club inconclusive NIPT twice deleting... Slightly less accurate for detecting trisomy 18 and 13 right, nipt test inconclusive twice hopefully the quad and...
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