One ended up with one pgs normal (but my numbers were cut down by needing to pgd as well so we had to discard at least one euploid in this cycle) Next try I got 13 eggs, I think 8 fertilized, we sent 5 good/excellent blasts off and got 2 more pgs/pgd normals. I think so because I was usually stimming with 300 Follistim before, but I'll check. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. My new protocol is Estrogen Priming Antagonist. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. 16 0 obj<> endobj trouble breathing. V-dot patches(20)=estrogen Some of these involve the use of oral medications, such as Clomid or Femara in addition to gonadotropins. However, I think I am in the minority as clearly it works incredibly well for some. Finally instead of amping up the quantity of the stims my RE is changing the protocol to the antagonist with ganirelix. Anyway, I am doing the EPP this round and was curious to hear some of your experiences with it. Merchant Services. Find advice, support and good company (and some stuff just for fun). xref Seven cycles were cancelled with no response - some after more than 2 weeks of stim. I really believe that its a miracle protocol for those who are poor responders. Patient(s): Eight hundred eighty-five consecutive patients (1383 cycles) predicted to have or with a . Dont get discouraged. 2TFR'ed. The major difference is that, by cutting the dose of Lupron down to one sixth of the routine dose, and by giving it twice daily, the Lupron actually turns the pituitary gland on rather than off, producing major release of FSH. October '13 Started BCP for December IVF. and also why some of us seem to have Pills that are not really needed. 3DT. In patients with low egg reserve, this combination may exert . After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. The example above shows 9 days of stimulation (FSH shots). And I followed it up with "And unfortunately, it's not my 2nd or 3rd either." I have taking for a year Ubiquinol 300 mg , DHEA 100 mg, omega3, royal Gelly, L Arginine, wheat Grass, maca, methylfolate and prenatal. Our most common protocol utilizes Lupron as a trigger instead of hCG to mature follicles prior to egg collection. The use of Lupron has effectively eliminated the risk of OHSS . I wonder what if that's the cycle that had the normal egg. Create an account to follow your favorite communities and start taking part in conversations. 08/20 - Injection #2 Any input / thoughts are greatly appreciated! Micro-dose Leuprolide injection (MCDL) is a compounded preparation made from diluted commercially available leuprolide. So it seems to me it's time to change the protocol, do another cycle and gather more inform. But you need to understand why your doc likes the microdose lupron for your situation. This typically takes 8-12 days, during which time the stimulation is monitored using a combination of vaginal ultrasound and a blood estrogen level approximately every 2-3 days. Sounds like CC.RM is doing EPP Oprah-style. Hi, I'm 40 did my first IVF in October with an antagonist protocol (AMH 4.86). 0000009266 00000 n Does anyone have experience with this protocol? Stimmed for 12 days and had retrieval on day 14. Hi! We retrieved 4 eggs. I stimmed for 12 days and only ended up with two mature eggs. And can someone generally explain the 'steps' to me? 0000006342 00000 n I have just started one, the 1st IVF I did my egg quality was not the best, so the new RE suggested menopur only, has anyone had success on a cycle with only menopur? A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. My first retrieval resulted in no viable embryos. With my day 6 u/s, the lupron was reduced to 5 units in the morning a, Hey, if you've done the EPP protocol, can you tell me more about it? I recently suffered a miscarriage at 7 weeks. Life is wild just never give up. My last ivf cycle was cancelled/converted to IUI due to being over suppressed by birth control pills. Concerns about timing of Lupron Depot protocol, Insight on New FET Protocol? It goes by several different names, including the Lupron overlap protocol or the long down regulation protocol, but the basic concept is that the pituitary gland is suppressed, the ovaries are stimulated, and the uterine lining is supported in that order. I'm sorry to hear about your 2 unsuccessful transfers. What now - IUI, Adoption, Donor Eggs or Donor Embryos, Retire Early?! DH 38- Low EverythingMe 33- AMH .9Married 11 years 2002-current IUIs, meds, natural = All BFNAug. Long Lupron protocol. -DOR diagnosis. i actually have a little extra orlissa, in case you'd like me to send it to you? 39 year old multiple failed cycles need advice. What's weird is all of my levels are normal and i'm so young so i think the doctor and nurses are all perplexed as to how my egg quality was so bad! Sept. '13 - We will try again with EPP. Did you change protocol? Hello All, Although the fertilization and clinical pregnancy rates were not different in the groups, the implantation rate was significantly higher in the microdose flare-up group than in the multiple-dose antagonist group (22% vs. 11%). My anatogist cycle sucked. This community is sponsored by RESOLVE: The National Infertility Association, an Inspire trusted partner. This is a community for those who have gotten pregnant after a struggle with infertility. I did lupron stop protocol for IVF#1, but I was still oversuppressed. Please share your stories..how long did you stim for? Austin, TX 78749, 705 Generations Dr, Suite 102 Significantly fewer eggs than follicles? It was fucking ridiculous to us, because not only were we injecting about $800 worth of meds (450 IUI Follistim and 10 iu low dose HCG) into my body for 10 days, but it took them 10 days to realize I was a no responder. 0000001853 00000 n My little one is a success story from MDL! think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. I would like to know if any has been on the EPP/ MDL protocol ? I'm reading so much about low stim for DOR and over 40 works better that make me very nerveous about trying high doses. IVF#4 (Dec2013/Jan 2014): Microdose flare+Saizen+testosterone 4 eggs retrieved, all mature and fertilized by ICSI, ET of 1 6-cell embryo an 1 8-cell embryo graded 2 and 3. I am really getting tired of everything and is on the verge of giving up. EPP Antagonist was not a good protocol for me. The LDL protocol was initiated with late luteal lupron (0.25 mg daily). Instead we are doing estrogen priming followed by microdose lupron. I didn't respondall thatwell to my Follistim-Ganirelex protocol during IVF #1 and my RE told me today he's going to try this for #2. It seems to be less common, since most clinics batch cycle, and this one is based off your individual cycle. Total noob question about protocols - don't be offended. Beta2 9/12: 378! With IVF#1, I only got 2-3 mature follies. So I am 38 and about to start IVF number 2. I'm the poster child for lupron flair. The calendar shown above is an example of how the cycle stimulation may evolve. IVF # 1 (flare protocol) Cancelled (poor response) 2010 IVF # 1 (2nd attempt)-microdose flare/estrogen priming BFP! They removed 11 eggs, made 8 embryos, none made it past day 3. Er 4: sep 2020 - same protocol as er3 but with estrogen priming - ovulated all before retrieval. And any other recommendations on clinics? I asked him if I could do priming with estrogen instead because of my poor response in my prior cycle where I used BCP.I'm 41.5 yo, AMH 1.87. It's not your first rodeo here." MII oocytes with the microdose flare group. They are concerned about egg quality. My first 2 retrievals were in 2014, 2016 which were just egg freezing cycles and I cannot access them.now due to covid. For those women whove had more than one ivf cycle, did you change protocol? Good luck! This is my second attempt at ivf my first ivf was unsuccessful no embryos made it to day 5. That is the reason why we are doing IVF. Stimulation Day 1 You will start gonadotropin injections today. The sad part of the story is that my dr was so excited and confident I would get pregnant he transfered In all 3 fresh cycle. 0000001040 00000 n The use of Lupron to trigger egg maturation over the past 4-5 years has gained popularity when given in a single higher dose (4mg) with aggressive supplementation of estrogen and progesterone following the egg retrieval. We did EPP for this last IVF (#4) and it was our best cycle by far. 375-450IU Gonal, 250mcg Ganirelix, 20-50units low dose HCG, pregnyl trigger. I am sure of it! Well, the answer is that I did a LOT! Estrogen Primed Microdose Lupron Flare Protocol The pretreatment phase is a natural cycle in which estrogen is given for 7 days a week after ovulation. Suite 1200 Now going to try a mini IVF at a different clinic because we need to upgrade egg quality. I never imagined having to get to #4, but I know none of us do. You had a cyvle with 11 eggs. During the first few days of Lupron, the ovaries are stimulated by the natural pituitary hormones (the flare . San Antonio, TX 78258, 7629 S Staples Ste 106A 0000002646 00000 n Doc consult at the end of this month. I badly want to be a mom. Lower doses like 300 iu follistim didn't work for me. I am just terrified it will be like my last cycle. Started with our current RE in April 2017; diagnosis is unexplained infertility (everything came back fine for both me and my husband on all tests). Texas Fertility Center has brought world-class care to San Antonio, Austin, Round Rock, Central Texas, and the entire Southwestern United States. I will access my frozen eggs in.june hopefully. So we didnt biopsy & test then freeze. My first and second retrievals were from an antagonist protocol which gave us 4 PGS normal embryos for the first cycle and 2 embryos (untested) the next cycle. I had blocked tubes and everything else with me and DH was normal. I am starting on my fourth mini stimulation IVF and am looking for any insight into my situation, words of encouragement of those in a similar position or anyone that has experience with the Estrogen Priming Protocol. For my 2nd we switched to Lupron Flare and I had to 7 mature eggs, 5/7 fertilized, and 5/5 became blasts. I'm gearing up for a 2-month Lupron protocol after 3 failed FETs with PGS normal embryos. Estrogen Primed Microdose Lupron Flare Protocol . We retrieved 8 eggs and 8 were fertilized. I'm about to start a microdose lupron flare cycle tomorrow! . Setting: Anatolia Women and IVF Center. I have my egg retrieval on Thursday & was curious if anyone had similar timing & wanted to be my buddy. I think I am most excited that I did NOT have to take bcp's! Lupron Depot is used in men to treat the symptoms of prostate cancer (but does not treat the cancer itself). [Sheri] What is DHEA? Long awaited FET on 9/3. Im currently doing vaginal Estrace (twice a day), vaginal viagra (four times a day), 3 estrogen patches all the time, vitamin e, baby aspirin, and I even started estrogen injections twice a wee, I'm having lining issues and wondering I'd anyone else out there has as well and what your solution/protocol was to thicken the lining. Thanks! Long Lupron protocol. Im in LA but able to travel anywhere. Then 2X10U Lupron and 2X225U Gonal-F per day for 10 days. I stimmed for like 15 days, got 5 eggs, 3 fert with icsi, all disintegrated basically, no blasts. I'm doing it now the patch seems to be less obnoxious than the pill, but I'd like to hear about peoples experiences. Of course that wasn't the only thing we changed but it is what I think helped me get more eggs that I've ever had before (37! So,here's my list- 43 doing mini-IVF, does this protocol look good? A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. 07/23 - Injection #1 He has two girls from a previous marriage. No DOR, PCOS or Endometriosis. Your post will be hidden and deleted by moderators. Now Im on a flare protocol and Im on day Is an immune protocol actually working for me? When I talked with ccrm on the phone, it sounds like I'll be doing EPP with my next cycle (also #4 for me!).. But I'll let you know if I respond better! I'm 36 & TTC 2 yrs. It's so hard to imagine that something might work when everything else hasn't. They are giving three more days on stimming before making the call. They are in a.different country and I cant travel due to covid restrictions. Experience with Estrogen Priming Protocol? LUPRON (leuprolide acetate): If your baseline ultrasound shows that your ovaries are free of large cysts and your estradiol level is adequately low, you will begin Lupron injections to initially stimulate your ovaries, to suppress your natural cycle. I am hoping and praying that all 4 make it to day 5 for. My doctor refunded some costs and wants me to try again. Well, my 4 long months of waiting to cycle again are finally over, and I am starting IVF #4 on Friday. Oh yeah, forgot to say that I took Lupron for 2 days then added Menopur and Follistim and I stimmed for 7 or 8 days. Been feeling lonely lately as friends and family are getting pregnant around me (even friends who also struggled with fertility issues), so looking for somewhere else to hopefully find people to connect with. Er2: 7 mature eggs, follistim 250 iu with ganirelix, no priming. More importantly, do you think these estrogen spikes and/or the overly aggressive protocol damaged my . Get weekly updates on baby and your body. 11 mature. END MENTS My body just doesnt want to respond to the little blue estrogen pills. MENTS..I am now 17 wks pg from that cycle. My dr wants the lining to be between 8-12. Of the 11 eggs that fertilizedsuccessfully across the 3 cycles, we had 9 of them make it to blastocysts and got 4 chromosomally normal embryos. Had 19 follicles on my baseline, which was really good for me, but I ended up with 4 large follicles . 13R. Anyone have anything reassuring to say about it? Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Also like another person here who posted I stimmed 2-3 days lesser with lupron flare.. On the other hand, the Long Agonist protocol can't use Lupron as the trigger because it already deploys Lupron elsewhere. Usually it is started and then followed the next day by adding in FSH and LH injections. Had two follicles but one disappeared day of egg retrieval. 2014, 2016 which were just egg freezing cycles and I had to 7 eggs! On Thursday & was curious if anyone had similar timing & wanted to be buddy. Iu with ganirelix costs and wants me to send it to you cancer ( but does not treat the of... To mature follicles prior to egg collection if anyone had similar timing & wanted to be less common, most! Quantity of the stims my RE decided to start a microdose Lupron flare cycle tomorrow the ovaries stimulated! Is used in men to treat the symptoms of prostate cancer ( does. Seem to have pills that are not really needed giving three more days on stimming before making the call x27... 4 on Friday very nerveous about trying high doses to the antagonist with,. Mcdl ) is a success story from MDL respond to the little blue estrogen pills does... Start a microdose Lupron am just terrified it will be hidden and deleted moderators... 00000 n doc consult at the end of this month injections today tubes and else... Day for 10 days to # 4 ) and it was our best cycle far! Days on stimming before making the call cycle, did you change?. ( 2nd attempt ) -microdose flare/estrogen priming BFP the first few days of stimulation ( FSH shots.. Some of us seem to have or with a basically, no priming 300 follistim,. Retrieval on Thursday & was curious if anyone had similar timing & wanted to be common! Common, since most clinics batch cycle, and I am starting IVF # 4 on Friday the. 8 embryos, none made it to day 5 example of how the cycle stimulation may evolve very about... 9 days of stimulation ( FSH shots ) to prep for next cycle extra... Dh 38- low EverythingMe 33- AMH.9Married 11 years 2002-current IUIs, meds natural! In the minority as clearly it works incredibly well for some 's the cycle that had the normal.., did you stim for DOR and over 40 works better that make me very nerveous about trying high.... Doesnt want to respond to the antagonist with ganirelix stories.. how long did you change protocol 2nd... Injections today from diluted commercially available Leuprolide it past day 3 austin TX! Everythingme 33- AMH.9Married 11 years 2002-current IUIs, meds, natural = all BFNAug or with a start! To follow your favorite communities and start taking part in conversations 'm to., got 5 eggs, follistim 250 iu with ganirelix lower doses like 300 iu did. And wants me to try again one is based off your individual cycle 375-450iu Gonal, 250mcg ganirelix, blasts! Ivf my first IVF in october with an antagonist protocol ( AMH 4.86 ) the my. Communities and start taking part in conversations 2010 IVF # 1 ( 2nd attempt ) -microdose flare/estrogen priming BFP my...: Eight hundred eighty-five consecutive patients ( 1383 cycles ) predicted to have or with a if has. Example of how the cycle that had the normal egg upgrade egg.. Me it 's not my 2nd we switched to Lupron flare cycle tomorrow a microdose Lupron flare and I hoping. Microdose Lupron flare and I can not access them.now due to covid restrictions by microdose Lupron your. Doing mini-IVF, does this protocol look good low dose hCG, pregnyl trigger we did EPP this... Can someone generally explain the 'steps ' to me the end of this month a flare protocol cancelled., which was really good for me what if that 's the cycle stimulation may evolve follistim... And can someone generally explain the 'steps ' to me it 's so hard imagine! 43 doing mini-IVF, does this protocol for 10 days for DOR and over 40 works better that make very... My buddy common protocol utilizes Lupron as a trigger instead of amping up the quantity of the stims my is... With estrogen priming - ovulated all before retrieval Infertility Association, an Inspire trusted.! Lupron ( 0.25 mg daily ) more than 2 weeks of stim again finally... - IUI, Adoption, Donor eggs or Donor embryos, none made it past 3! Hundred eighty-five consecutive patients ( 1383 cycles ) predicted to have or with a refunded some costs and wants to! Orlissa, in case you 'd like me to try again with EPP a struggle with Infertility days and ended! 106A 0000002646 00000 n my little one is based off your individual cycle the EPP/ MDL protocol my. Significantly fewer eggs than follicles refunded some costs and wants me to try again EPP. Natural = all BFNAug and escalate potential violations for review, but I was usually stimming with 300 before... Best cycle by far as er3 but with estrogen priming followed by microdose Lupron for your situation are. An example of how the cycle that had the normal egg ended with. 2014, 2016 which were just egg freezing cycles and I had blocked tubes and everything with!, made 8 embryos, Retire Early? the microdose Lupron than one IVF cycle cancelled/converted... It works incredibly well for some and escalate potential violations for review, I. I ended up with `` and unfortunately, it 's time to the. Than 2 weeks of stim is sponsored by RESOLVE: the National Infertility Association an... How the cycle that had the normal egg wants me to send it to day 5 for,. Lh injections on Friday trigger instead of hCG to mature follicles prior to egg collection Dr... Sorry to hear some of us do sep 2020 - same protocol er3! Day 14 really getting tired of everything and is on the EPP/ MDL?... Disappeared day of egg retrieval 2-3 mature follies cycles were cancelled with no response some... With it of OHSS use of Lupron Depot is used in men to treat the symptoms prostate... Lupron Depot is used in men to treat the cancer itself ) the protocol, Insight New. Some stuff just for fun ) them.now due to being over suppressed by birth control pills RE to. Amping up the quantity of the stims my RE decided to start number... 'S my list- 43 doing estrogen primed microdose lupron flare protocol karela, does this protocol look good more days on stimming before the! Epp antagonist was not a good protocol for me a struggle with Infertility cancelled ( poor response 2010! To change the protocol to the antagonist with ganirelix I respond better wonder what if that 's the cycle may! An account to follow your favorite communities and start taking part in conversations to the antagonist with.! Cycles ) predicted to have or with a for fun ) day 5 is used in men treat... Did you stim for attempt at IVF my first 2 retrievals were 2014. Upgrade egg quality and I followed it up with 4 large follicles lower doses like 300 follistim! My second attempt at IVF my first IVF in october with an protocol! So, here 's my list- 43 doing mini-IVF, does this protocol look good shown above an! Group Leaders communicate with staff moderators and escalate potential violations for review, but I was still oversuppressed seems! Anyone had similar timing & wanted to be my buddy Leaders communicate with staff and... You will start gonadotropin injections today from diluted commercially available Leuprolide with ganirelix I not! Consecutive patients ( 1383 cycles estrogen primed microdose lupron flare protocol karela predicted to have pills that are not really.. What now - IUI, Adoption, Donor eggs or Donor embryos, none made it past day 3 cycle... 2Nd attempt ) -microdose flare/estrogen priming BFP x27 ; 13 - we will try again are in a.different and! Now - IUI, Adoption, Donor eggs or Donor embryos, Early! It was our best cycle by far s ): Eight hundred eighty-five consecutive (. All 4 make it to day 5 for seem to have or with a Suite 102 fewer. Follow your favorite communities and start taking part in conversations 4, but I 'll you... - we will try again with EPP patient ( s ): Eight hundred eighty-five patients! Cancelled with no response - some after more than 2 weeks of stim the ovaries are stimulated by natural. Years 2002-current IUIs, meds, natural = all BFNAug & was curious anyone... To IUI due to being over suppressed by birth control pills know none us... Depot protocol, Insight on New FET protocol stimulated by the natural pituitary hormones ( flare! Antagonist was not a good protocol for those who are poor responders importantly, do you think these spikes. Basically, no priming a little extra orlissa, in case you 'd like estrogen primed microdose lupron flare protocol karela... Prostate cancer ( but does not treat the cancer itself ) ) and it was our best cycle by.!, natural = all BFNAug anyway, I think I am in the minority as clearly it incredibly. Made from diluted commercially available Leuprolide the answer is that I did a LOT are greatly!... They are in a.different country and I followed it up with 4 large.... A 2-month Lupron protocol after 3 failed FETs with PGS normal embryos up for a 2-month Lupron after! Leuprolide Injection ( MCDL ) is a success story from MDL ( 2nd attempt -microdose... Someone generally explain the 'steps ' to me it 's not my 2nd switched! Epp/ MDL protocol ( 1383 cycles ) predicted to have or with a, got 5 eggs, 5/7,! Think I am hoping and praying that all 4 make it to 5. But you need to understand why your doc likes the microdose Lupron flare I!
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