2017). A Detailed History of Intron-rich Eukaryotic Ancestors Inferred from a Global Survey of 100 Complete Genomes. A top-down method for building genome classification trees with linear binary hierarchies. IMPALA: matching a protein sequence against a collection of PSI-BLAST-constructed position-specific score matrices. The goal of this trial is to edit the patient’s own T cells via CRISPR-Cas9 technology as a part of a cancer therapy protocol (Reardon 2016). Biol Direct 6:32. https://doi.org/10.1186/1745-6150-6-32, Pourcel C, Salvignol G, Vergnaud G (2005) CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies. Cell 168:20–36.
She agrees that CRISPR-Cas offers to date a prime example of a phenomenon of inheritance of acquired genomic characters. Mathematical Methods Of Analysis Of Biopolymer Sequences. Follow this author.

Microbial genome analysis: the COG approach. While we did signal Twitter to not track our users by setting the "dnt" flag, we do not have any control over how Twitter uses your data. Add a list of references from , , and to record detail pages. In “A Use/Disuse Paradigm for CRISPR-Cas Systems”, Sophie Veigl (2018) narrows down the criteria for counting as a “Lamarckian” phenomenon, and then proposes that interference-driven spacer acquisition (IDSA) could be seen as an instantiation of a truly Lamarckian paradigm.

Dependencies among Editing Sites in Serotonin 2C Receptor mRNA. Their combined citations are counted only for the first article. Yet, this fantastic toolkit also raises several important issues. ATGC database and ATGC-COGs: an updated resource for micro- and macro-evolutionary studies of prokaryotic genomes and protein family annotation. The following articles are merged in Scholar. ... Eugene Koonin Senior Investigator, NCBI, ... EV Koonin…

Fast and reliable reconstruction of phylogenetic trees with very short edges. Add open access links from to the list of external document links (if available). 2007). Add co-authors Co-authors. The COG database: a tool for genome-scale analysis of protein functions and evolution.

Google Scholar, Barrangou R, Fremaux C, Deveau H et al (2007) CRISPR provides acquired resistance against viruses in prokaryotes. Comparison of Phylogenetic Trees and Search for a Central Trend in the "Forest of Life". Their combined citations are counted only for the first article. There is indeed little doubt that the characterization of the CRISPR-Cas systems and their mechanisms constitutes a ground-breaking discovery in recent biological and biomedical sciences, from basic microbiology to technological applications (Doudna and Charpentier 2014). Please see Google's Terms of Service posted at http://www.google.com/terms_of_service.html

The following articles are merged in Scholar. load references from crossref.org and opencitations.net. New citations to this author. Although we do not have any reason to believe that your call will be tracked, we do not have any control over how the remote server uses your data. He is a recognised expert in the field of evolutionary and computational biology. Genome analysis using clusters of orthologous groups (COGs). https://doi.org/10.1007/s10539-018-9658-7, Beatty J (2016) The creativity of natural selection? Cite this article. Koonin is a prominent biologist and an expert in evolutionary and computational biology. Search. Microbiol Read Engl 151:653–663. Nucleic Acids Res 30:482–496, Makarova KS, Grishin NV, Shabalina SA et al (2006) A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. Second, CRISPR-Cas-based immunity concerns activities that go beyond defence, such as DNA repair. Koautor hinzufügen Koautoren.
For more information see our F.A.Q. 2015). https://doi.org/10.1099/mic.0.27437-0, Pradeu T, Moreau JF (2018) CRISPR-Cas immunity: beyond nonself and defence. Pradeu, T. Philosophy of CRISPR-Cas: Introduction to Eugene Koonin’s target paper and commentaries. PDF Restore Delete Forever. Biology & Philosophy A natural taxonomy of gene families from complete genomes. The following articles are merged in Scholar. of Internal Medicine, University of genova, Italy Verified email at neurologia.unige.it pasquale vito Università del Sannio Verified email at unisannio.it https://doi.org/10.1126/science.aal4222, Doudna JA, Charpentier E (2014) The new frontier of genome engineering with CRISPR-Cas9. In a nutshell, CRISPR-Cas makes it possible for many prokaryotes to detect and eliminate viruses (known as phages, in the case of bacteria) and to respond more efficiently if the same virus is encountered for a second time. We are most grateful to Eugene Koonin for having accepted to write for Biology & Philosophy a target paper on such a major topic in current biology as CRISPR-Cas (CRISPR-Cas stands for “Clustered Regularly Interspaced Short Palindromic Repeats”). The ones marked * may be different from the article in the profile. Mol Cell 60:385–397. Koonin’s work also has a strong conceptual and philosophical dimension, as illustrated by his book, The Logic of Chance (Koonin 2011), many of his scientific papers [e.g., (Koonin and Wolf 2010; Koonin and Krupovic 2015)], and also by his publications in philosophy of science journals [e.g., (Koonin and Starokadomskyy 2016)] or in collaboration with philosophers (O’Malley and Koonin 2011). Science 315:1709–1712. PubMed Google Scholar. Koonin’s paper is followed by a series of selected commentaries, written by biologists of different backgrounds and philosophers of biology. Finally, they propose that a key feature of CRISPR-Cas systems is that they do hold the potential for a genuinely non-Darwinian, directed evolution, but one that differs from what Koonin describes, and that is based instead on the use of CRISPR-Cas as a human gene-editing tool. Second, after distinguishing three meanings of “Lamarckism”, they reject the view that the CRISPR-Cas system would be “Lamarckian”, particularly because it does not exhibit the kind of teleological connotation usually associated by Lamarckism. https://doi.org/10.1007/s10539-018-9660-0, Jablonka E, Gissis S (2011) Transformations of lamarckism: from subtle fluids to molecular Biology. CRISPR-Cas: the discovery of an immune system in prokaryotes. Comparative Analysis of Biopolymer Sequences: Reflections on the Validity of the Methodology and the Underlying General Principles. Only living authors are included. J Mol Evol 60:174–182. “It’s effectively a devotion or dedication to creative but rational thinking. Taken together, these results led to the now commonly accepted concept that CRISPR-Cas is a prokaryotic adaptive immune system, endowed with a form of immune “memory” (Hille et al. Try again later.

So please proceed with care and consider checking the Internet Archive privacy policy. By now, CRISPR-Cas has been widely adopted as a gene-editing tool in labs across the world, and many students learn how to use it. The ones marked. Their combined citations are counted only for ... Eugene Koonin. You are currently offline. Expanded microbial genome coverage and improved protein family annotation in the COG database. https://doi.org/10.1007/s10539-018-9659-6, Woolley S, Parke EC, Kelley D, Poole AM, Ganley A (2018) Striving for clarity about the “Lamarckian” nature of CRISPR-Cas systems. Presence of ATG triplets in 5' untranslated regions of eukaryotic cDNAs correlates with a 'weak' context of the start codon. It comes as no surprise, therefore, that, at present, CRISPR-Cas technologies are actively discussed by bioethicists, regulatory bodies, and the public more generally [e.g., (Belluck 2017)]. https://doi.org/10.1007/s10539-018-9661-z, Wideman JG, Inkpen SA, Doolittle WF, Redfield RJ (2018) Mutationism, not Lamarckism, captures the novelty of CRISPR-Cas. Science 346:1258096. https://doi.org/10.1126/science.1258096, Gayon J (1998) Darwinism’s struggle for survival: heredity and the hypothesis of natural selection.

Predictability of Evolutionary Trajectories in Fitness Landscapes. Prediction of an rRNA methyltransferase domain in human tumor-specific nucleolar protein P120. 2015; Mohanraju et al. The following articles are merged in Scholar. 2006; Barrangou et al. Skip to search form Skip to main content Semantic Scholar. The system can't perform the operation now. Nature Reviews Microbiology 13 (11), 722-736. This series of papers ends with Eugene Koonin’s response to commentaries. You need to opt-in for them to become active. MIT Press, Cambridge, Komor AC, Badran AH, Liu DR (2017) CRISPR-based technologies for the manipulation of eukaryotic genomes. Additionally, she emphasizes how Lamarckian and quasi-Lamarckian processes, including CRISPR-Cas, influence evolvability. Folgende Artikel sind in Scholar zusammengeführt. The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria. A simple tool to search for sequence motifs that are conserved in BLAST outputs. Koonin is a prominent biologist and an expert in evolutionary and computational biology. This "Cited by" count includes citations to the following articles in Scholar. Zusammengeführte Zitate. In the first commentary, “Mutationism, not Lamarckism, captures the novelty of CRISPR-Cas”, Jeremy Wideman, Andrew Inkpen, Ford Doolittle, and Rosemary Redfield (Wideman et al. Biol Direct 1:7. https://doi.org/10.1186/1745-6150-1-7, Makarova KS, Aravind L, Wolf YI, Koonin EV (2011a) Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems. Nature Reviews Microbiology 9 (6), 467-477, AF Neuwald, L Aravind, JL Spouge, EV Koonin. last updated on 2020-09-12 03:04 CEST by the dblp team, all metadata released as open data under CC0 1.0 license, see also: Terms of Use | Privacy Policy | Imprint. Nat Rev Genet 16:184–192. She offers a conceptually and historically enriched characterization of “Lamarckism” and “quasi-Lamarckism” [see also (Jablonka and Gissis 2011)]. 2013; Doudna and Charpentier 2014; Komor et al. What is the meaning of the colors in the publication lists? Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eucaryotes and archaebacteria. So please proceed with care and consider checking the Twitter privacy policy. On these debates, see (Gayon 1998; Beatty 2016). Die kombinierten Zitate werden nur für den ersten Artikel gezählt.


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