x|–”Ğ|êqÿ8:°8¶ºj` z½Ù¹Ñ5¹]I„®å듼çr9, Statement on the Scientific Validity of the EPISKIN Test. Our news gives you an insight into our support of EU policy and highlights the scientific research carried out everyday within the European Commission. 1. 9 0 obj Specialised Working Groups (WGs) of ESAC are set up ad hoc to prepare ESAC peer reviews and document their findings in "ESAC WG Reports". Coordination of independent scientific peer review by the EURL ECVAM Scientific Advisory Committee (ESAC). /Height 75 Major categories of EURL ECVAM activities: Duties and tasks of the Union Reference Laboratory as specified in Annex VII of Directive 2010/63/EU are the following: EURL ECVAM’s validation process, from submission of a test method to final ECVAM recommendations, was updated in March 2013 as explained on the “EURL ECVAM Validation Process” page. At its 10th meeting, held on 31 March 1998 at the European Centre for the Validation of Alternative Methods (ECVAM),Ispra, Italy, the ECVAM Scientific Advisory Committee (ESAC)1unanimously endorsed the following statement: The results obtained with the rat skin transcutaneous electrical resistance (TER) test in the ECVAM international validation study onin vitrotests for skin corrosivity were reproducible, … The European Centre for the Validation of Alternative Methods (ECVAM) is one of 5 units in the Institute for Health and Consumer Protection (IHCP) in Ispra, Italy. ESTAF: The EURL ECVAM Stakeholder Forum (ESTAF) is composed of 16 non-governmental stakeholders. /Subtype /Image During the process, stakeholders, international partners and also test method submitters are involved at key stages, so that their views but also their technical and scientific input is taken into account to the extent possible. /ColorSpace /DeviceRGB Each chemical was tested twice, independently, according to the principles of GLP, and coded data were submitted to the Humboldt University (Berlin, Germany) for biostatistical analysis. General information about the ECVAM skin corrosivity validation study: A. conducting research and collaborating in EU and international research initiatives; coordination and undertaking of validation studies of. As a multinational and multicultural research centre, we collaborate with over a thousand partners worldwide. This publication is a Science for Policy report by the Joint Research Centre (JRC), the European Commission’s science and knowledge service. ICATM: EURL ECVAM is one of the five validation bodies that are members to the 2009 agreement, the International Cooperation on Alternative Test Methods (ICATM), with the goal of promoting international cooperation on the validation of methods that replace and reduce animals in toxicity testing. specific use in an ITS or the regulatory context). PARERE will meet once per year and will have joint meetings with ESTAF. a !1AQa"q�2���B#$Rb34�r�C%�S��cs5��&D�TdE£t6�U�e���u��F'���������������Vfv��������7GWgw��������(8HXhx�������� )9IYiy�������� ESTAF meets once per year to participate in advocacy and dialogue on ECVAM’s activities. *:JZjz���������� �� ? Finalisation of EURL ECVAM Recommendations balancing, in an impartial manner, EURL ECVAM's own position with all other input received (ESAC, stakeholders, test method submitters, general public, international partners). The ESTAF was established in April 2011 “to foster participatory engagement with its non-regulatory stakeholders.” The stakeholder community is a major source of test submissions for ECVAM validation. European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM) laboratory EURL ECVAM has contributed to the validation of the test methods listed below. Validation is at the interface between test method development/optimisation and regulatory acceptance/international recognition and ensures a science-based and conscientious evaluation of test methods and approaches (e.g.

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